Female Infertility and Serum Auto-antibodies - A Systematic Review
- April 22,2022
- 2 Min Read
SUBURBAN JOURNAL CLUB
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Journal Article: Female Infertility & Serum Auto-antibodies: A Systematic Review
Journal: Clinical Reviews In Allergy & Immunology, Volume 53; Pg. No.: 78-86
The fertility of a couple is defined as their ability to obtain a pregnancy. In humans, fertilizability (monthly probability of initiating a pregnancy) is difficult to estimate but is thought to be about 20% to 30%.
The 12-month rate of infertility (absence of pregnancy despite regular unprotected sexual intercourse) is estimated as 9% worldwide.
The causes of infertility can be divided into three main categories for which the prevalence is variable:
- Female causes (33% to 41%)
- Male causes (25% to 39%)
- Mixed causes (9% to 39%)
The contribution of serum auto-antibodies to infertility remains debated, but some data tend to show its role in infertilities classified as idiopathic.
The authors of this journal article have performed a comprehensive literature review to assess the association of auto-antibodies in female infertility and assisted reproduction.
Table 1: Summary of data available for serum auto-antibodies, in case of infertility, IVF or ICSI-IVF.
APL: anti-phospholipid; TPO: thyroperoxydase; TG: thyroglobulin; ANA: anti-nuclear antibodies; B2-GP1: beta-2-glycoprotein-1; ASCA: anti-Saccharomyces cerevisiae antibodies; CD: celiac disease; IVF: in vitro fertilization; ICSI-IVF: intracytoplasmic sperm injection-IVF; NA: not available
Table 2: Simplified auto-immune tests proposed for infertile women at admission to an ART program.
TSH: thyroid stimulating hormone; TPO: thyroperoxidase; TG: thyroglobulin; ANA: anti-nuclear antibodies, B2-GP1: beta-2-glycoprotein-1; ASCA: anti-Saccharomyces cerevisiae antibodies; ANCA: anti-neutrophil cytoplasmic antibodies. The recommendations in italics have not been proven and have been proposed by the authors of the review article.
The full article can be accessed at: https://link.springer.com/article/10.1007/s12016-016-8586-z