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Anti HEV (Hepatitis E Virus) Antibody, IgM, Serum

Anti HEV (Hepatitis E Virus) Antibody, IgM, Serum

This test is used to diagnose Hepatitis E infection

Test Schedule: 
Cut-off time: 

Information for Healthcare Professionals:


Infectious Disease, Hepatobiliary, Gastrointestinal, Internal Medicine

Intended Use

This test detects the presence of antibodies against Hepatitis E Virus

Clinical Significance

After an incubation period ranging from 15 to 60 days, HEV-infected patients develop symptoms of hepatitis with appearance of anti-HEV IgM antibody in serum, followed by detectable anti-HEV IgG within a few days. Anti-HEV IgM may remain detectable up to 6



Reference Range

Non Reactive


Reactive results confirm the presence of acute or recent (in the preceding 6 months) hepatitis E infection. Non Reactive results indicate absence of acute or recent hepatitis E infection.

Specimen and Specimen Volume

2 ml Serum

Transport Container

Gel with Clot Activator Tube (Yellow Top or Red Top with Yellow Ring) / Plain Tube (Red Top)

Specimen Stability (Ambient)


Specimen Stability (2-8°C)

7 Days

Specimen Stability (-20°C)

30 Days

Collection Instruction

Observe universal precautions when collecting a blood specimen. Record the time of day when the blood test is drawn. Follow the recommended order of draw when collecting blood in tubes. To obtain valid results, do not fasten the tourniquet for longer than 1 minute. Release and remove the tourniquet as soon as possible after the blood begins to flow. Prolonged tourniquet application can cause stasis and hemoconcentration. Wrap the tourniquet around the arm 3 to 4 inches (7.5 to 10.0 cm) above the venepuncture site. If a blood pressure cuff is used in place of a tourniquet, inflate it to no more than 40mm Hg. The veins become more prominent and easier to enter when the patient forms fist. However, there must not be vigorous hand exercise (pumping) - vigorous hand pumping can cause changes in the concentration of certain analytes in the blood. The preferred venepuncture site is the antecubital fossa. Mix additive tubes by inversion. Do not shake the blood specimen. Hemolysis may result from vigorous shaking and can invalidate test results. Use gentle inversions. Collect the blood specimen from the arm without an intravenous (IV) device, if possible. IV infusion can influence test results. Do not use the arm bearing a dialysis arteriovenous fistula for venepuncture unless the physician specifically authorizes it. Because of the risk of cellulitis, do not take specimens from the side on which a mastectomy or axillary lymph node dissection was performed.

Rejection Criteria

Grossly hemolyzed, icteric or lipemic specimens, Quantity not sufficient, Mislabelled or Unlabelled specimens
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