{"id":2183,"date":"2024-12-06T05:06:38","date_gmt":"2024-12-06T05:06:38","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=2183"},"modified":"2025-03-05T10:16:13","modified_gmt":"2025-03-05T10:16:13","slug":"incidence-of-hemoglobinopathies","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/incidence-of-hemoglobinopathies\/","title":{"rendered":"Understanding the Incidence of Hemoglobinopathies"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-2200\" src=\"https:\/\/suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-300x180.webp\" alt=\"\" width=\"1343\" height=\"806\" title=\"\" srcset=\"https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-300x180.webp 300w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-768x461.webp 768w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp 1000w\" sizes=\"(max-width: 1343px) 100vw, 1343px\" \/><\/p>\n<p style=\"font-weight: 400;\">Hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule.<\/p>\n<p style=\"font-weight: 400;\"><b>There are 2 major types:<\/b><\/p>\n<ul style=\"font-weight: 400;\">\n<li aria-level=\"1\"><b>Quantitative abnormalities<\/b>: Disorders of decreased globin chain production. <b>Eg<\/b>: Thalassemias (\u03b1, \u03b2, \u03b4, \u03b4\u03b2)<\/li>\n<li aria-level=\"1\"><b>Qualitative abnormalities<\/b>: Structural variant hemoglobins present. <b>Eg<\/b>: HbS (Sickle cell), HbD Punjab, HbE, HbQ India, etc.<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u00a0<b>Acquired hemoglobinopathies:<\/b><\/p>\n<p style=\"font-weight: 400;\">These are not inherited and are caused due to certain physiological states, deficiencies or diseases.<\/p>\n<ul style=\"font-weight: 400;\">\n<li aria-level=\"1\">Elevated HbF: Pregnancy, stress hemopoiesis, acute leukemia, JMML, cell-cycle specific drugs<\/li>\n<li aria-level=\"1\">Elevated HbA2: Vit B12 deficiency<\/li>\n<li aria-level=\"1\">Low HbA2: Iron deficiency<\/li>\n<li aria-level=\"1\">Acquired HbH: MDS and AML<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">They can potentially influence the levels of normal and abnormal hemoglobins in inherited hemoglobinopathies if present concurrently.<\/p>\n<p style=\"font-weight: 400;\">The Suburban Diagnostics CoE for Hematology conducted a retrospective study of all cases of hemoglobin analysis conducted by HPLC between 2015 and 2021 to identify the incidence of various hemoglobinopathies. From 34,000+ samples, we found that the 6 year incidence of hemoglobinopathies was <b>13.3%<\/b>. The 6 year incidence of some of the major hemoglobinopathies include:<\/p>\n<ul style=\"font-weight: 400;\">\n<li aria-level=\"1\">Beta Thalassemia Trait:\u00a0 8.8%*<\/li>\n<li aria-level=\"1\">Beta Thalassemia Homozygous:\u00a0 0.1%<\/li>\n<li aria-level=\"1\">Sickle Cell Heterozygous: 0.8%*<\/li>\n<li aria-level=\"1\">Sickle Cell Homozygous: 0.2%<\/li>\n<li aria-level=\"1\">Hemoglobin D Punjab Heterozygous: 0.4%*<\/li>\n<li aria-level=\"1\">Hemoglobin D Punjab Homozygous: 0.01%<\/li>\n<li aria-level=\"1\">Hemoglobin E Heterozygous: 0.4%*<\/li>\n<li aria-level=\"1\">Hemoglobin E Homozygous: 0.05%<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">*These percentages do not include double heterozygous cases.<\/p>\n<p style=\"font-weight: 400;\">#unburdenhealthcare with us.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. There are 2 major types: Quantitative abnormalities: Disorders of decreased globin chain production. Eg: Thalassemias (\u03b1, \u03b2, \u03b4, \u03b4\u03b2) Qualitative abnormalities: Structural variant hemoglobins present. Eg: HbS (Sickle cell), HbD Punjab, HbE,<span class=\"post-excerpt-end\">&hellip;<\/span><\/p>\n<p class=\"more-link\"><a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/incidence-of-hemoglobinopathies\/\" class=\"themebutton\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":2200,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Understanding-the-Incidence-of-Hemoglobinopathies-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Suburban","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/\" rel=\"category tag\">For Doctors<\/a>","rttpg_excerpt":"Hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. There are 2 major types: Quantitative abnormalities: Disorders of decreased globin chain production. Eg: Thalassemias (\u03b1, \u03b2, \u03b4, \u03b4\u03b2) Qualitative abnormalities: Structural variant hemoglobins present. Eg: HbS (Sickle cell), HbD Punjab, HbE,&hellip;Read&hellip;","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=2183"}],"version-history":[{"count":4,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2183\/revisions"}],"predecessor-version":[{"id":4325,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2183\/revisions\/4325"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/2200"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=2183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=2183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=2183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}