{"id":2177,"date":"2024-12-06T04:51:31","date_gmt":"2024-12-06T04:51:31","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=2177"},"modified":"2025-03-05T10:15:41","modified_gmt":"2025-03-05T10:15:41","slug":"importance-of-hpv-dna-in-cervical-cancer-screening","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/importance-of-hpv-dna-in-cervical-cancer-screening\/","title":{"rendered":"Importance of HPV DNA Testing in Cervical Cancer Screening"},"content":{"rendered":"

\"\"<\/p>\n

In India, cervical cancer accounts for 9.4% of all cancers.<\/b><\/p>\n

1,23,907 new cases of cervical cancer were detected in 2020.<\/b><\/p>\n

Suburban Diagnostics conducted a 5-year study on pap smears done using liquid-based cytology (PAP SurePath LBC) and analyzed whether there was an association between the diagnosis and the presence or absence of HPV DNA in the same samples.<\/p>\n

The results were as follows:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
PAP LBC Report\u00a0<\/b><\/td>\nPercentage<\/b><\/td>\n<\/tr>\n
NILM<\/td>\n96.42%<\/td>\n<\/tr>\n
ASC-US<\/td>\n2.29%<\/td>\n<\/tr>\n
ASC-H<\/td>\n0.18%<\/td>\n<\/tr>\n
LSIL<\/td>\n0.59%<\/td>\n<\/tr>\n
HSIL<\/td>\n0.20%<\/td>\n<\/tr>\n
SCC<\/td>\n0.12%<\/td>\n<\/tr>\n
Other (atypical glandular or endometrial cells)<\/td>\n0.18%<\/td>\n<\/tr>\n
TOTAL<\/b><\/td>\n100%<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n
PAP LBC Report<\/b><\/td>\nHPV DNA<\/b><\/td>\n<\/tr>\n
HPV DNA Detected<\/b><\/td>\nHPV DNA Not Detected<\/b><\/td>\n<\/tr>\n
NILM<\/td>\n4.18%<\/td>\n95.82%<\/td>\n<\/tr>\n
ASC-US<\/td>\n15.32%<\/td>\n84.68%<\/td>\n<\/tr>\n
ASC-H<\/td>\n22.22%<\/td>\n77.78%<\/td>\n<\/tr>\n
LSIL<\/td>\n35.71%<\/td>\n64.29%<\/td>\n<\/tr>\n
HSIL<\/td>\n70.00%<\/td>\n30.00%<\/td>\n<\/tr>\n
SCC<\/td>\n66.67%<\/td>\n33.33%<\/td>\n<\/tr>\n
Other (atypical glandular or endometrial cells)<\/td>\n22.22%<\/td>\n77.78%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

The prevalence of HPV infection among women with normal cervical cytology was found to be 4.18%<\/b>.<\/p>\n

Analysis revealed a statistically significant association between HPV DNA and diagnosis on PAP LBC<\/b> (p<0.001)<\/b>.<\/p>\n

Reports of ASC-H, ASC-US, HSIL, LSIL, and SCC were higher in cases where HPV DNA was detected.<\/b><\/p>\n

However, on deeper analysis, we found that knowing only the PAP LBC report would not help us in predicting whether the patient has an HPV infection<\/b>.<\/p>\n

In fact, having the knowledge of a patient\u2019s PAP LBC report will lead to only a 2.9% decrease in error<\/b> in our ability to predict the HPV status of the patient.<\/p>\n

If HPV DNA is detected, genotyping should be done to identify the HPV strain (high-risk strains include: 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70). High-risk type HPV-16 and 18 contribute over 70% of all cervical cancer cases.<\/p>\n

Most guidelines also recommend primary HPV screening or co-testing:<\/b><\/p>\n\n\n\n\n\n
RCOG<\/b><\/td>\nACOG<\/b><\/td>\nFOGSI<\/b><\/td>\n<\/tr>\n
Screening to start from 25 years of age.<\/td>\nScreening to start from 21 years of age.<\/td>\nScreening to start from 25 years of age.<\/td>\n<\/tr>\n
Primary HPV screening from 25-64 years.<\/p>\n

Every 3 years from 25-49 years and every 5 years from 50-64 years.<\/td>\n

For women between 30-65 years, primary HPV DNA testing or co-testing every 5 years or cytology alone every 3 years.<\/p>\n

For women in the 21-29 years of age group, only cytology will suffice.<\/td>\n

Primary HPV DNA testing or cytology from the age of 25 years.<\/p>\n

Primary HPV DNA testing or co-testing every 5 years for women between 30-65 years of age group.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

TAKE HOME MESSAGE:<\/b><\/p>\n

Co-testing or HPV DNA testing SHOULD be the preferred method of screening.<\/b><\/p>\n

Doing a PAP LBC by itself is not enough.<\/b><\/p>\n

#unburdenhealthcare with us.\u00a0<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

In India, cervical cancer accounts for 9.4% of all cancers. 1,23,907 new cases of cervical cancer were detected in 2020. Suburban Diagnostics conducted a 5-year study on pap smears done using liquid-based cytology (PAP SurePath LBC) and analyzed whether there was an association between the diagnosis and the presence or absence of HPV DNA in…<\/span><\/p>\n

Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":2178,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Importance-of-HPV-DNA-Testing-in-Cervical-Cancer-Screening-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Suburban","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"For Doctors<\/a>","rttpg_excerpt":"In India, cervical cancer accounts for 9.4% of all cancers. 1,23,907 new cases of cervical cancer were detected in 2020. Suburban Diagnostics conducted a 5-year study on pap smears done using liquid-based cytology (PAP SurePath LBC) and analyzed whether there was an association between the diagnosis and the presence or absence of HPV DNA in…Read…","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=2177"}],"version-history":[{"count":3,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2177\/revisions"}],"predecessor-version":[{"id":4321,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2177\/revisions\/4321"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/2178"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=2177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=2177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=2177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}