{"id":2172,"date":"2024-12-06T04:48:03","date_gmt":"2024-12-06T04:48:03","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=2172"},"modified":"2025-03-05T10:15:33","modified_gmt":"2025-03-05T10:15:33","slug":"trends-in-drug-resistant-tb-6-year-study","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/trends-in-drug-resistant-tb-6-year-study\/","title":{"rendered":"Trends in Drug-Resistant TB A 6-Year Study"},"content":{"rendered":"

\"\"<\/p>\n

Tuberculosis (TB) is the leading cause of death from a single infectious disease agent and the leading cause of death among persons living with human immunodeficiency virus (HIV) infection.<\/p>\n

According to the World Health Organization (WHO), 27% of the global TB cases are from India.<\/b><\/p>\n

One of the biggest challenges in treating tuberculosis is the rising rate of drug resistance in the 1st and 2nd line drugs and pose a serious threat to the #EndTB initiative.<\/p>\n

Mono-resistant TB: <\/b>Resistant to a single first-line anti-TB drug (isoniazid, rifampicin, ethambutol, or pyrazinamide).<\/p>\n

Multidrug-resistant tuberculosis (MDR-TB)<\/b>: Resistant to at least rifampicin and isoniazid.<\/p>\n

Extensively drug-resistant tuberculosis (XDR-TB)<\/b>: Resistant to isoniazid and rifampicin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin).<\/p>\n

Suburban Diagnostics conducted a 6-year study <\/b>on positive TB culture samples<\/b> to understand the profile of drug resistance between the years 2015 and 2021.<\/p>\n

Mono-resistant TB<\/b><\/p>\n

The combined rates of mono-resistant TB (resistant to ONLY a single 1st line drug) seem to be on the rise.<\/p>\n

Overall, the 7-year rate of mono-resistant TB: 5.3%<\/b><\/p>\n

The most common 1st line drugs for which mono-resistance was seen were pyrazinamide and INH.<\/p>\n

MDR-TB<\/b><\/p>\n

Overall, the 7-year rate of MDR-TB: 35.7%<\/b><\/p>\n

We found the rates of MDR-TB have been decreasing over the years.<\/p>\n

XDR-TB<\/b><\/p>\n

Overall, the 7-year rate of XDR-TB: 3.4%<\/b><\/p>\n

10.6% of MDR cases were also XDR.<\/b><\/p>\n

We found the rates of XDR-TB have been decreasing since a peak in 2018.<\/p>\n

UPDATED XDR-TB DEFINITION<\/b><\/p>\n

The WHO updated the definition of XDR-TB in 2021. The new definition of XDR-TB (applicable from 2021 onwards) is as follows:<\/p>\n

TB is caused by Mycobacterium tuberculosis strains that fulfil the definition of MDR\/RR-TB and which are also resistant to any fluoroquinolone and at least one additional group A drug (group A drugs are the most potent group of drugs in the ranking of second-line medicines for the treatment of drug-resistant forms of TB using longer treatment regimens and comprise levofloxacin, moxifloxacin, bedaquiline, and linezolid).<\/i><\/b><\/p>\n

As per the NTEP (National Tuberculosis Elimination Programme) 2021 guidelines for programmatic management of drug-resistant tuberculosis in India, molecular genotypic tests are the preferred method for the detection of drug resistance.<\/p>\n

At Suburban Diagnostics, we offer the cutting edge GeneXpert MTB\/XDR.<\/b><\/p>\n

Advantages of using GeneXpert MTB\/XDR test:<\/b><\/p>\n

    \n
  1. Faster time to result for molecular DST.<\/li>\n
  2. Detect mutations associated with resistance towards isoniazid (INH), fluoroquinolones (FLQ), second-line injectable drug (SLID) (amikacin, kanamycin, capreomycin), and ethionamide (ETH) in a single test.<\/li>\n
  3. One simple sputum sample for a full spectrum of TB diagnostics.<\/li>\n
  4. All clinically relevant answers are available to select the right treatment based on the patient\u2019s MTB strain.<\/li>\n
  5. Fast laboratory results mean fast initiation of appropriate treatment.<\/li>\n<\/ol>\n

    Let us join hands to #EndTB<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

    Tuberculosis (TB) is the leading cause of death from a single infectious disease agent and the leading cause of death among persons living with human immunodeficiency virus (HIV) infection. According to the World Health Organization (WHO), 27% of the global TB cases are from India. One of the biggest challenges in treating tuberculosis is the…<\/span><\/p>\n

    Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":2173,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Trends-in-Drug-Resistant-TB-A-6-Year-Study-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Suburban","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"For Doctors<\/a>","rttpg_excerpt":"Tuberculosis (TB) is the leading cause of death from a single infectious disease agent and the leading cause of death among persons living with human immunodeficiency virus (HIV) infection. According to the World Health Organization (WHO), 27% of the global TB cases are from India. One of the biggest challenges in treating tuberculosis is the…Read…","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=2172"}],"version-history":[{"count":5,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2172\/revisions"}],"predecessor-version":[{"id":4320,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2172\/revisions\/4320"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/2173"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=2172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=2172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=2172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}