{"id":2127,"date":"2024-12-06T04:19:43","date_gmt":"2024-12-06T04:19:43","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=2127"},"modified":"2026-08-28T14:10:33","modified_gmt":"2026-08-28T14:10:33","slug":"female-infertility-and-serum-auto-antibodies-a-systematic-review","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/female-infertility-and-serum-auto-antibodies-a-systematic-review\/","title":{"rendered":"Female Infertility and Serum Auto-antibodies &#8211; A Systematic Review"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-2145\" src=\"https:\/\/suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-300x180.webp\" alt=\"\" width=\"1322\" height=\"793\" title=\"\" srcset=\"https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-300x180.webp 300w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-768x461.webp 768w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp 1000w\" sizes=\"(max-width: 1322px) 100vw, 1322px\" \/><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.suburbandiagnostics.com\/blog\/female-infertility-and-serum-auto-antibodies-a-systematic-review\/#SUBURBAN_JOURNAL_CLUB\" >SUBURBAN JOURNAL CLUB<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.suburbandiagnostics.com\/blog\/female-infertility-and-serum-auto-antibodies-a-systematic-review\/#Table_1_Summary_of_data_available_for_serum_auto-antibodies_in_case_of_infertility_IVF_or_ICSI-IVF\" >Table 1: Summary of data available for serum auto-antibodies, in case of infertility, IVF or ICSI-IVF.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.suburbandiagnostics.com\/blog\/female-infertility-and-serum-auto-antibodies-a-systematic-review\/#Table_2_Simplified_auto-immune_tests_proposed_for_infertile_women_at_admission_to_an_ART_program\" >Table 2: Simplified auto-immune tests proposed for infertile women at admission to an ART program.<\/a><\/li><\/ul><\/nav><\/div>\n<h2 style=\"font-weight: 400\"><span class=\"ez-toc-section\" id=\"SUBURBAN_JOURNAL_CLUB\"><\/span><b>SUBURBAN JOURNAL CLUB<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p style=\"font-weight: 400\"><b>A monthly precis of some of the best, most influential journal articles.<\/b><\/p>\n<p style=\"font-weight: 400\"><b>Journal Article<\/b>: Female Infertility &amp; Serum Auto-antibodies: A Systematic Review<\/p>\n<p style=\"font-weight: 400\"><b>Journal<\/b>: Clinical Reviews In Allergy &amp; Immunology, Volume 53; Pg. No.: 78-86<\/p>\n<p style=\"font-weight: 400\"><b>DOI<\/b>: 10.1007\/s12016-016-8586-z<\/p>\n<p style=\"font-weight: 400\">The fertility of a couple is defined as their ability to obtain a pregnancy. In humans, fertilizability (monthly probability of initiating a pregnancy) is difficult to estimate but is thought to be about 20% to 30%.<\/p>\n<p style=\"font-weight: 400\">The 12-month rate of infertility (absence of pregnancy despite regular unprotected sexual intercourse) is estimated as 9% worldwide.<\/p>\n<p style=\"font-weight: 400\">The causes of <a href=\"https:\/\/www.suburbandiagnostics.com\/health-library\/infertility\">infertility<\/a> can be divided into three main categories for which the prevalence is variable:<\/p>\n<ul style=\"font-weight: 400\">\n<li>Female causes (33% to 41%)<\/li>\n<li>Male causes (25% to 39%)<\/li>\n<li>Mixed causes (9% to 39%)<\/li>\n<\/ul>\n<p style=\"font-weight: 400\">The contribution of serum auto-antibodies to infertility remains debated, but some data tend to show its role in infertilities classified as idiopathic.<\/p>\n<p style=\"font-weight: 400\">The authors of this journal article have performed a comprehensive literature review to assess the association of auto-antibodies in female infertility and assisted reproduction.<\/p>\n<h2 style=\"font-weight: 400\"><span class=\"ez-toc-section\" id=\"Table_1_Summary_of_data_available_for_serum_auto-antibodies_in_case_of_infertility_IVF_or_ICSI-IVF\"><\/span><i>Table 1: Summary of data available for serum auto-antibodies, in case of infertility, IVF or ICSI-IVF.<\/i><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td>&nbsp;<\/td>\n<td><b>Anti-Phospholipid Antibodies (APL)<\/b><\/td>\n<td><b>Anti-Nuclear Antibodies (ANA)<\/b><\/td>\n<td><b>Anti-tissue antibodies<\/b><\/td>\n<td><b>Thyroid auto-antibodies<\/b><\/td>\n<td><b>Anti-ovarian antibodies<\/b><\/td>\n<td><b>Others<\/b><\/td>\n<\/tr>\n<tr>\n<td>Female infertility<\/td>\n<td>\n<p>Higher prevalence in infertile females (12% vs. 2% in normal).<\/p>\n<p>Weak influence of APL in fertility.<\/p>\n<\/td>\n<td>Increased prevalence seen in female infertility (20% vs. 3% in normal fertile women).<\/td>\n<td>Higher prevalence of anti-smooth muscle antibodies (35% vs. 3% infertile women).<\/td>\n<td>Higher prevalence of anti-TPO and anti-TG (16% in infertile population).<\/td>\n<td>Higher prevalence, especially in women with early ovarian insufficiency.<\/td>\n<td>Higher prevalence of ASCA and of CD associated auto-antibodies.<\/td>\n<\/tr>\n<tr>\n<td>IVF<\/td>\n<td>\n<p>Higher prevalence of anti-beta-2-GP1 level (20%).<\/p>\n<p>But, no association between APL and the results of IVF.<\/p>\n<\/td>\n<td>\n<p>Lower rate of implantation and pregnancy (14% vs. 32.4% in normal fertile women).<\/p>\n<p>Positive correlation between ANA level and fertility rate.<\/p>\n<\/td>\n<td>NA<\/td>\n<td>Lower rate of fertilization implantation and pregnancy.<\/td>\n<td>Higher prevalence.<\/td>\n<td>NA<\/td>\n<\/tr>\n<tr>\n<td>ICSI-IVF<\/td>\n<td>No association between APL and ICSI-IVF.<\/td>\n<td>NA<\/td>\n<td>NA<\/td>\n<td>No difference in the prognosis of ICSI-IVF.<\/td>\n<td>NA<\/td>\n<td>NA<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 400\"><i>APL: anti-phospholipid; TPO: thyroperoxydase; TG: thyroglobulin; ANA: anti-nuclear antibodies; B2-GP1: beta-2-glycoprotein-1; ASCA: anti-Saccharomyces cerevisiae antibodies; CD: celiac disease; IVF: in vitro fertilization; ICSI-IVF: intracytoplasmic sperm injection-IVF; NA: not available<\/i><\/p>\n<h2 style=\"font-weight: 400\"><span class=\"ez-toc-section\" id=\"Table_2_Simplified_auto-immune_tests_proposed_for_infertile_women_at_admission_to_an_ART_program\"><\/span><i>Table 2: Simplified auto-immune tests proposed for infertile women at admission to an ART program.<\/i><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td><b>Auto-immune pathology<\/b><\/td>\n<td><b>Assays<\/b><\/td>\n<\/tr>\n<tr>\n<td>Auto-immune endocrinopathy<\/td>\n<td>TSH, T3, T4, anti-TPO antibodies, anti-TG antibodies, plasma cortisol<\/td>\n<\/tr>\n<tr>\n<td>Aspecific auto-immunity<\/td>\n<td>ANA, anti-tissue antibodies, complements (CH50, C3, C4), <i>serum protein electrophoresis<\/i><\/td>\n<\/tr>\n<tr>\n<td>Anti-phospholipid antibodies<\/td>\n<td>Lupus anticoagulant, anti-cardiolipin antibody, anti-B2-GP1 antibody, <i>blood platelet count, TPHA-VDRL, anti-prothrombin, anti-phosphatidylserine antibody<\/i><\/td>\n<\/tr>\n<tr>\n<td>Celiac disease-associated antibodies<\/td>\n<td>IgA and IgG anti-transglutaminase antibodies, IgA and IgG anti-endomysial antibodies<\/td>\n<\/tr>\n<tr>\n<td>Other<\/td>\n<td><i>ASCA, ANCA<\/i><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 400\">TSH: thyroid stimulating hormone; TPO: thyroperoxidase; TG: thyroglobulin; ANA: anti-nuclear antibodies, B2-GP1: beta-2-glycoprotein-1; ASCA: anti-Saccharomyces cerevisiae antibodies; ANCA: anti-neutrophil cytoplasmic antibodies. The recommendations in italics have not been proven and have been proposed by the authors of the review article.<\/p>\n<p style=\"font-weight: 400\">The full article can be accessed at: <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12016-016-8586-z\" target=\"_blank\" rel=\"noopener\">https:\/\/link.springer.com\/article\/10.1007\/s12016-016-8586-z<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SUBURBAN JOURNAL CLUB A monthly precis of some of the best, most influential journal articles. Journal Article: Female Infertility &amp; Serum Auto-antibodies: A Systematic Review Journal: Clinical Reviews In Allergy &amp; Immunology, Volume 53; Pg. No.: 78-86 DOI: 10.1007\/s12016-016-8586-z The fertility of a couple is defined as their ability to obtain a pregnancy. In humans,<span class=\"post-excerpt-end\">&hellip;<\/span><\/p>\n<p class=\"more-link\"><a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/female-infertility-and-serum-auto-antibodies-a-systematic-review\/\" class=\"themebutton\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":2145,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/Female-Infertility-and-Serum-Auto-antibodies-A-Systematic-Review-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Team Suburban Diagnostics","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/\" rel=\"category tag\">For Doctors<\/a>","rttpg_excerpt":"SUBURBAN JOURNAL CLUB A monthly precis of some of the best, most influential journal articles. Journal Article: Female Infertility &amp; Serum Auto-antibodies: A Systematic Review Journal: Clinical Reviews In Allergy &amp; Immunology, Volume 53; Pg. No.: 78-86 DOI: 10.1007\/s12016-016-8586-z The fertility of a couple is defined as their ability to obtain a pregnancy. In humans,&hellip;Read&hellip;","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=2127"}],"version-history":[{"count":5,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2127\/revisions"}],"predecessor-version":[{"id":4870,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2127\/revisions\/4870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/2145"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=2127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=2127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=2127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}