{"id":2125,"date":"2024-12-06T04:16:49","date_gmt":"2024-12-06T04:16:49","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=2125"},"modified":"2025-03-05T10:10:45","modified_gmt":"2025-03-05T10:10:45","slug":"rapid-tb-diagnosis","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/rapid-tb-diagnosis\/","title":{"rendered":"TB Diagnosis Using GeneXpert and GeneXpert Ultra"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-2140\" src=\"https:\/\/suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-300x180.webp\" alt=\"\" width=\"1263\" height=\"758\" title=\"\" srcset=\"https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-300x180.webp 300w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-768x461.webp 768w, https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp 1000w\" sizes=\"(max-width: 1263px) 100vw, 1263px\" \/><\/p>\n<p style=\"font-weight: 400;\"><b><a href=\"https:\/\/www.suburbandiagnostics.com\/services\/diagnostics-services\">Initial diagnostic tests<\/a> with sample type as recommended by the WHO:<\/b>(1)<\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Adults\/Children<\/b><\/td>\n<td><b>Disease<\/b><\/td>\n<td><b>Recommended Samples<\/b><\/td>\n<td><b>Recommended Test(s)<\/b><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Adults\/Children<\/p>\n<p>(with or without a history of TB)<\/td>\n<td>Signs and symptoms of PTB\/chest radiograph with lung abnormalities<\/td>\n<td>\n<ul>\n<li>Ideal sample: Sputum<\/li>\n<li>Alternative samples (only in those who cannot produce sputum):\n<ul>\n<li>Nasopharyngeal aspirate<\/li>\n<li>Gastric aspirate<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/td>\n<td rowspan=\"3\">GeneXpert<\/p>\n<p>MTB\/RIF<\/p>\n<p>or<\/p>\n<p>GeneXpert Ultra MTB\/RIF<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Signs and symptoms of EPTB<\/td>\n<td rowspan=\"2\">\n<ul>\n<li>CSF<\/li>\n<li>Lymph node aspirate<\/li>\n<li>Lymph node biopsy<\/li>\n<li>Pleural fluid<\/li>\n<li>Peritoneal fluid<\/li>\n<li>Pericardial fluid<\/li>\n<li>Synovial fluid<\/li>\n<li>Urine<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 400;\">PTB \u2013 Pulmonary TB; EPTB \u2013 Extrapulmonary TB<\/p>\n<p style=\"font-weight: 400;\"><b>GeneXpert and GeneXpert Ultra are the recommended tests for Rapid TB Diagnosis.<\/b>(1)<\/p>\n<p style=\"font-weight: 400;\">In case of a negative result on GeneXpert Ultra, <b>broth-based culture can be done if there still exists a strong clinical suspicion of TB<\/b>. (1)<\/p>\n<p><strong>Performance of GeneXpert &amp; GeneXpert Ultra MTB\/RIF (according to the WHO):<\/strong><sup>(1)<\/sup><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Adults\/Children<\/strong><\/td>\n<td><strong>Disease<\/strong><\/td>\n<td><strong>Sample<\/strong><\/td>\n<td><strong>GeneXpert<\/strong><\/p>\n<p><strong>MTB\/RIF Sensitivity<\/strong><\/td>\n<td><strong>GeneXpert Ultra<\/strong><\/p>\n<p><strong>MTB\/RIF Sensitivity<\/strong><\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"12\">Adults<\/td>\n<td>PTB<\/td>\n<td>Sputum<\/td>\n<td>85%<\/td>\n<td>90%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB &#8211; Smear Negative<\/td>\n<td>Sputum<\/td>\n<td>67%<\/td>\n<td>77%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB &#8211; HIV +ve<\/td>\n<td>Sputum<\/td>\n<td>81%<\/td>\n<td>88%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>CSF<\/td>\n<td>70%<\/td>\n<td>87%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Lymph node aspirate<\/td>\n<td>89%<\/td>\n<td>78%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Lymph node biopsy<\/td>\n<td>82%<\/td>\n<td>90% &#8211; 100%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Pleural fluid<\/td>\n<td>50%<\/td>\n<td>71%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Peritoneal fluid<\/td>\n<td>59%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Pericardial fluid<\/td>\n<td>66%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>EPTB<\/td>\n<td>Synovial fluid<\/td>\n<td>97%<\/td>\n<td>96%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">EPTB<\/td>\n<td rowspan=\"2\">Urine<\/td>\n<td rowspan=\"2\">85%<\/td>\n<td rowspan=\"2\">100%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"8\">Children<\/td>\n<td>PTB<\/td>\n<td>Sputum<\/td>\n<td>65%<\/td>\n<td>73%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB<\/td>\n<td>Gastric aspirate<sup>#<\/sup><\/td>\n<td>73%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB<\/td>\n<td>Nasopharyngeal aspirate<\/td>\n<td>46%<\/td>\n<td>46%<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB &#8211; Smear Negative<\/td>\n<td>Sputum<\/td>\n<td>59%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB &#8211; HIV +ve<\/td>\n<td>Sputum<\/td>\n<td>72%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td>PTB &#8211; HIV +ve<\/td>\n<td>Gastric aspirate<sup>#<\/sup><\/td>\n<td>73%<\/td>\n<td>Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">EPTB<\/td>\n<td rowspan=\"2\">CSF<\/td>\n<td rowspan=\"2\">54%<\/td>\n<td rowspan=\"2\">Not Available*<\/td>\n<td width=\"0\"><\/td>\n<\/tr>\n<tr>\n<td width=\"0\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>* <\/strong>&#8211; Sensitivity not published by the WHO<\/p>\n<p># &#8211;\u00a0 Gastric aspiration is not used for adults; it can be useful in children who cannot produce sputum.<\/p>\n<p style=\"font-weight: 400;\"><b>GeneXpert MTB\/RIF Ultra is the new, next generation GeneXpert test for TB:<\/b><\/p>\n<ul style=\"font-weight: 400;\">\n<li>Improved performance<\/li>\n<li>10-fold improvement in the lower limit of TB detection<\/li>\n<li>Higher sensitivity, especially in smear negative cases<\/li>\n<li>Increased accuracy of rifampicin resistance results<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\"><b>REFERENCES<\/b><\/p>\n<ol style=\"font-weight: 400;\">\n<li>World Health Organization. WHO consolidated guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection [Internet]. 2021 update. Geneva: World Health Organization; 2021 [cited 2022 Mar 16]. Available from: https:\/\/apps.who.int\/iris\/handle\/10665\/342331<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Initial diagnostic tests with sample type as recommended by the WHO:(1) Adults\/Children Disease Recommended Samples Recommended Test(s) Adults\/Children (with or without a history of TB) Signs and symptoms of PTB\/chest radiograph with lung abnormalities Ideal sample: Sputum Alternative samples (only in those who cannot produce sputum): Nasopharyngeal aspirate Gastric aspirate GeneXpert MTB\/RIF or GeneXpert Ultra<span class=\"post-excerpt-end\">&hellip;<\/span><\/p>\n<p class=\"more-link\"><a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/rapid-tb-diagnosis\/\" class=\"themebutton\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":2140,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/12\/TB-Diagnosis-Using-GeneXpert-and-GeneXpert-Ultra-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Suburban","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/\" rel=\"category tag\">For Doctors<\/a>","rttpg_excerpt":"Initial diagnostic tests with sample type as recommended by the WHO:(1) Adults\/Children Disease Recommended Samples Recommended Test(s) Adults\/Children (with or without a history of TB) Signs and symptoms of PTB\/chest radiograph with lung abnormalities Ideal sample: Sputum Alternative samples (only in those who cannot produce sputum): Nasopharyngeal aspirate Gastric aspirate GeneXpert MTB\/RIF or GeneXpert Ultra&hellip;Read&hellip;","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=2125"}],"version-history":[{"count":8,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2125\/revisions"}],"predecessor-version":[{"id":4312,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/2125\/revisions\/4312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/2140"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=2125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=2125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=2125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}