{"id":1284,"date":"2024-11-27T11:23:23","date_gmt":"2024-11-27T11:23:23","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=1284"},"modified":"2025-03-05T10:06:12","modified_gmt":"2025-03-05T10:06:12","slug":"risk-for-thromboembolism-in-hereditary-and-acquired-thrombophilias","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/risk-for-thromboembolism-in-hereditary-and-acquired-thrombophilias\/","title":{"rendered":"Thrombophilias: Guide to Hereditary and Acquired Conditions"},"content":{"rendered":"

\"\"<\/p>\n

Thrombophilias may be hereditary or acquired and the risk\/severity of thrombosis varies widely between conditions.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Hereditary Thrombophilia<\/b><\/td>\nRelative Risk For A First Venous Thromboembolism (Compared To Community Controls)<\/b><\/td>\n<\/tr>\n
Factor V Leiden<\/p>\n
    \n
  • Heterozygous<\/li>\n
  • Homozygous<\/li>\n<\/ul>\n<\/td>\n
3x \u2013 7x
\n80x<\/td>\n<\/tr>\n
Prothrombin G20210A<\/p>\n
    \n
  • Heterozygous<\/li>\n
  • Homozygous<\/li>\n<\/ul>\n<\/td>\n
2x \u2013 3x<\/p>\n

5x<\/td>\n<\/tr>\n

Double heterozygosity (Factor V Leiden and prothrombin G20210A)<\/td>\n6x<\/td>\n<\/tr>\n
Antithrombin deficiency<\/td>\n5x<\/td>\n<\/tr>\n
Protein C deficiency<\/td>\n4x \u2013 6.5x<\/td>\n<\/tr>\n
Protein S deficiency<\/td>\n1x \u2013 3x<\/td>\n<\/tr>\n
Pseudohomozygous Factor V Leiden<\/td>\n80x<\/td>\n<\/tr>\n
Factor IX Padua<\/td>\n10x<\/td>\n<\/tr>\n
Antithrombin resistance<\/td>\n2x \u2013 3x<\/td>\n<\/tr>\n
Factor VIII \u2265150 IU\/dl<\/td>\n3x \u2013 5x<\/td>\n<\/tr>\n
Factor IX \u2265129 IU\/dl<\/td>\n2.3x<\/td>\n<\/tr>\n
Factor XI \u2265121 IU\/dl<\/td>\n2x<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Adapted from: Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Expert Rev Hematol. 2019 Mar 4;12(3):147\u201358.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Acquired Thrombophilia<\/b><\/td>\nRelative Risk For A First Venous Thromboembolism (Compared To Community Controls)<\/b><\/td>\n<\/tr>\n
Antiphospholipid antibody syndrome<\/td>\n3x \u2013 10x<\/td>\n<\/tr>\n
Hyperhomocysteinemia<\/td>\n1.5x \u2013 3x<\/td>\n<\/tr>\n
Surgery<\/td>\n1.7x \u2013 2.8x<\/td>\n<\/tr>\n
Trauma<\/td>\n3x \u2013 5x<\/td>\n<\/tr>\n
Pregnancy<\/td>\n5x \u2013 50x<\/td>\n<\/tr>\n
Estrogen-progestogen therapies<\/td>\n2x \u2013 9x<\/td>\n<\/tr>\n
Cancer<\/td>\n4x \u2013 7x<\/td>\n<\/tr>\n
Myeloproliferative neoplasms<\/td>\n3x<\/td>\n<\/tr>\n
Economy class syndrome (DVT on long haul flights)<\/td>\n2x \u2013 4x<\/td>\n<\/tr>\n
Obesity (BMI \u226530 Kg\/m2)<\/td>\n2x \u2013 3x<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Adapted from: Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Expert Rev Hematol. 2019 Mar 4;12(3):147\u201358.<\/p>\n","protected":false},"excerpt":{"rendered":"

Thrombophilias may be hereditary or acquired and the risk\/severity of thrombosis varies widely between conditions. Hereditary Thrombophilia Relative Risk For A First Venous Thromboembolism (Compared To Community Controls) Factor V Leiden Heterozygous Homozygous 3x \u2013 7x 80x Prothrombin G20210A Heterozygous Homozygous 2x \u2013 3x 5x Double heterozygosity (Factor V Leiden and prothrombin G20210A) 6x Antithrombin…<\/span><\/p>\n

Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":1292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,9],"tags":[],"class_list":["post-1284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-doctors","category-recent-articles"],"blog_post_layout_featured_media_urls":{"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-150x150.webp",150,150,true],"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false]},"categories_names":{"5":{"name":"For Doctors","link":"https:\/\/www.suburbandiagnostics.com\/blog\/for-doctors\/"},"9":{"name":"Recent Articles","link":"https:\/\/www.suburbandiagnostics.com\/blog\/recent-articles\/"}},"tags_names":[],"comments_number":"0","rttpg_featured_image_url":{"full":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"landscape":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"portraits":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"thumbnail":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-150x150.webp",150,150,true],"medium":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-300x180.webp",300,180,true],"large":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"1536x1536":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"2048x2048":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb.webp",1000,600,false],"shuttle-column1-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-1000x380.webp",1000,380,true],"shuttle-column1-1\/4":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-1000x285.webp",1000,285,true],"shuttle-column2-1\/2":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-570x285.webp",570,285,true],"shuttle-column2-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-570x380.webp",570,380,true],"shuttle-column3-1\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-380x107.webp",380,107,true],"shuttle-column3-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-380x254.webp",380,254,true],"shuttle-column4-2\/3":["https:\/\/www.suburbandiagnostics.com\/blog\/wp-content\/uploads\/2024\/11\/60b8e4c8-c7d9-4370-b16c-b8f07eda7eeb-285x190.webp",285,190,true]},"rttpg_author":{"display_name":"Suburban","author_link":"https:\/\/www.suburbandiagnostics.com\/blog\/author\/suburban\/"},"rttpg_comment":0,"rttpg_category":"For Doctors<\/a> Recent Articles<\/a>","rttpg_excerpt":"Thrombophilias may be hereditary or acquired and the risk\/severity of thrombosis varies widely between conditions. Hereditary Thrombophilia Relative Risk For A First Venous Thromboembolism (Compared To Community Controls) Factor V Leiden Heterozygous Homozygous 3x \u2013 7x 80x Prothrombin G20210A Heterozygous Homozygous 2x \u2013 3x 5x Double heterozygosity (Factor V Leiden and prothrombin G20210A) 6x Antithrombin…Read…","_links":{"self":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/1284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/comments?post=1284"}],"version-history":[{"count":3,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/1284\/revisions"}],"predecessor-version":[{"id":4302,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/posts\/1284\/revisions\/4302"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media\/1292"}],"wp:attachment":[{"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/media?parent=1284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/categories?post=1284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.suburbandiagnostics.com\/blog\/wp-json\/wp\/v2\/tags?post=1284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}