{"id":1282,"date":"2024-11-27T11:19:55","date_gmt":"2024-11-27T11:19:55","guid":{"rendered":"https:\/\/suburban-blog.abymtech.com\/?p=1282"},"modified":"2025-03-05T10:06:29","modified_gmt":"2025-03-05T10:06:29","slug":"maternal-screening-overview","status":"publish","type":"post","link":"https:\/\/www.suburbandiagnostics.com\/blog\/maternal-screening-overview\/","title":{"rendered":"Maternal Screening Overview: Understanding the Importance and Benefits"},"content":{"rendered":"

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n
Parameters<\/b><\/td>\nDual Marker<\/b><\/td>\nEFTS<\/b><\/td>\nQuadruple Marker<\/b><\/td>\nNIPT<\/b><\/td>\n<\/tr>\n
Ideal gestational period<\/b><\/td>\n11 weeks to 13 weeks, 6 days<\/td>\n11 weeks to 13 weeks, 6 days<\/td>\n15 weeks to 21 weeks, 6 days<\/td>\n10 weeks to term<\/td>\n<\/tr>\n
Biochemical values<\/b><\/td>\nPAPP-A<\/p>\n

Free beta HCG<\/td>\n

PAPP-A<\/p>\n

Free beta HCG<\/p>\n

AFP<\/p>\n

PIGF<\/td>\n

PAPP-A<\/p>\n

Free beta HCG<\/p>\n

uE3<\/p>\n

Inhibin-A<\/td>\n

No biochemical testing \u2013 sequencing of fetal fraction DNA in the maternal circulation<\/td>\n<\/tr>\n
Bio-physical values required and acceptable range<\/b><\/td>\nNT: less than 3 mm<\/p>\n

CRL: 42 \u2013 83<\/p>\n

mm<\/td>\n

CRL: 45 \u2013 84 mm<\/p>\n

NT: less than 3 mm<\/p>\n

UTPI: 0.4 \u2013 4<\/p>\n

MAP for pre-eclampsia<\/td>\n

BPD: 31 \u2013 52 mm<\/td>\nNA<\/td>\n<\/tr>\n
Detection rate<\/b><\/td>\n91%<\/td>\n90%<\/td>\n75%<\/td>\n>99.9%<\/td>\n<\/tr>\n
False positive rate<\/b><\/td>\n5%<\/td>\n1.4%<\/td>\n5%<\/td>\n<1%<\/td>\n<\/tr>\n
Clinical indication<\/b><\/td>\nEarly detection of down syndrome, edward syndrome, patau syndrome, and other aneuploidies.<\/td>\nFetal aneuploidies, structural defects, and pre-eclampsia.<\/td>\nIdentifies risk for down syndrome, edward syndrome, patau syndrome, and neural tube defect syndrome.<\/td>\nScreening test for fetal aneuploidies like down syndrome, edward syndrome, and patau syndrome.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

AFP<\/b> \u2013 Alpha-fetoprotein; BPD<\/b> \u2013 Biparietal diameter; CRL<\/b> \u2013 Crown rump length; HCG<\/b> \u2013 Human chorionic gonadotropin; MAP<\/b> \u2013 Mean-arterial pressure; NT<\/b> \u2013 Nuchal translucency; PAPP-A<\/b> \u2013\u00a0 Pregnancy associated plasma protein; PIGF<\/b> \u2013 Placental growth factor; uE3<\/b> \u2013 Unconjugated estradiol; UTPI<\/b> \u2013 Uterine artery pulsatility index; NIPT <\/b>\u2013 Non-invasive prenatal testing<\/p>\n

References:<\/b><\/p>\n