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POLYCYSTIC OVARIAN SYNDROME (PCOS) IS NOT A “COSMETIC” OR “INFERTILITY” CONDITION, IT CAN BE WORSE

  • FACIAL HAIR GROWTH ADOLESCENCE
  • Irregular painful cycles
  • ACNE
  • DIABETES & CARDIAC PROBLEMS
  • A lot of weight gain which cannot come off easily

It is known that women with PCOS are significantly more likely to have type II diabetes, thyroid, and heart disease and it also appears to have a link to endometrial cancer.

1 in every 5 women in India is estimated to have PCOS. As it is a cluster of disorders, no single test can diagnose the condition. PCOS diagnosis requires a battery of laboratory and radiological tests, the results of which need to be clinically correlated.

Lab tests for PCOS
  • Testosterone
    • Androgen excess can be tested by measuring total & free testosterone levels
    • An elevated free testosterone level is a sensitive indicator of androgen excess
  • DHEA – S
    • Most normal or slightly high in PCOS
    • If > 800 mcg/dl, consider adrenal tumor
  • LH/FSH ratio
    • Levels vary over menstrual cycle, released in pulsatile fashion, affected by OCPs
    • LH/FSH ratio > 2 has little diagnostics sensitivity and need not be documented
  • TSH – To detect Hypothyroidism
  • Prolactin – To detect Hyperprolactinemia
  • Hypdroxyprogresterone (r/o if > 200 ng/dl) – Late onset congenital adrenal hyperplasia
  • Cortisol – Cushing’s Syndrome
Diagnosis of PCOS is incomplete without USG Examination
  • Ultrasound Criteria for Polycystic Ovaries
    • Polycystic Ovarian morphology: presence of 12 follicles of 2 – 9mm diameters and/or ovarian volume > 10mL without a cyst or dominant follicle > 10mm
    • Polycystic ovaries not specific for PCOS, & > 20% of normal women have incidental polycystic ovaries
Risk stratification of PCOS Patients

The AE – PCOS SOCIETY recommends all women with PCOS to be assessed for CVD risk, to test for BMI, waist conference and blood pressure at each clinical visit.

Suburban Diagnostics offers a comprehensive evaluation of PCOS
PCOS – Profile 1 PCOS – Profile 2 PCOS – Profile 3
Irregular cycles with suspended hyperandrogenism Classic PCOS/Ovulatory PCOS (with USG) Classic PCOS/Ovulatory PCOS (with USG)
FBS, PPBS, HOMA, Free testosterone, FSH, LH, Prolactine, 17OHP FBS, PPBS, HOMA, Free testosterone, FSH, LH, Prolactine, 17OHP, Androstenedione, DHEAS, DHT, Lipid Profile, FT3, FT4, TSH, SHBG, Cortisol, AMH FBS, PPBS, HOMA, Free testosterone, FSH, LH, Prolactine, 17OHP, Androstenedione, DHEAS, DHT, Lipid Profile, FT3, FT4, TSH, SHBG, Cortisol, AMH, USG Pelvis

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