New born Screening

Nearly 2100 babies are born every hour in India. More than 3400 infants a day – suffer from a congenital abnormality
If left undetected and untreated, these disorders will likely claim most of these young lives by age five
If detected in the first few days after birth, those infants may be given a healthy start to life

NEWBORN SCREENING: Restoring the right to a healthy childhood

Suburban Diagnostics in association with PerkinElmer (a global leader in newborn screening with over 30 years of experience) offers complete Newborn screening range
Detects over 50 metabolic disorders
Uses VICTOR 2D (time resolved Fluorometry) and MS/MS (Tandem Mass Spectroscopy) delivering high sensitivity and reproducibility of results
Complete solution provider – from sample to result with expert interpretation of results
Complete solution provider – from sample to result with expert interpretation of results
Over 500 million babies screened using PerkinElmer solutions worldwide

Can detect metabolic conditions after 48 hours of age and within 15 days
Sample collection is safe and simple – a heel prick on specially designed DBS card

Disorder Screened	Effected if not screened	Effect if screened and managed	Management
Congenital Hypothyroidism	Severe mental retardation, intellectual disability and abnormal growth	Normal – if treatment begins in the first month after birth	Daily oral dose thyroid hormone (thyroxine)
Congenital Adernal Hypothyroidism	Death, muscle wasting and dehyderation, Hisutism and abnormal enlargement of genitals	Normal with medication	Hydrocortisone / Liquid prednisolone in infancy and childhood prednisone or Dexamethasone in adults
Glucose -6-phospate Dehydrogenase Deficiency	Severe Anaemia, Prolonged neonatal Jaundice, Kernicterus	Normal with dietary and medical restrictions	Immediate exclusive of dietary galactose
Cystic Fibrosis	Chronic obstructive lung disease, airway infections, gastrointestinal abnoramalities	Dramatic improvement in the qualities of life with early diagnosis, treatment and diet management	Phenylalanine – restricted food with proper dietary control under close supervision of the dietician / physician, lifelong
Biotinidase Deficiency	Hypotonia, ataxia, seizures, development delays, vision/hearing loss, alopecia, dermatitis	Normal with supplements	Oral Biotin adminstration. This treatment is lifelong and highly effective

1 in 1500 to 3000 newborns suffer from Inborn Errors of Metabolism

Newborn Screening: Expanded Panel – Inborn Errors of Metabolism

A comprehensive screening program for clinically significant disorders performed using MS/MS (Tandem Mass Spectrometer), the most widely used technique for IEM testing
Detects more than 50 disorders which includes
- 11 Amino Acid disorders
- 13 Acylcarnitines (Fatty Acid disorders)
- Organic Acid disorders
- Hemoglobinopathies
- Newborn Screening: Basic Panel