If one foetus is aborted, we need to look for the foetal pole. If the foetal pole is present in the demised twin, the dual test is not possible as there will be production of substances (PAPP-A & Free βhCG) from the demised twin and the resulting interpretation will be erroneous. Foetal pole needs 8-9 weeks to close in cases where one foetus in aborted. If there is no foetal pole we can take the pregnancy as a singleton and the dual test can be processed.
Monochorionic twins originate from the same embryo, so they are assumed to be genetically identical although there is the difference in biometry.
FMF guidelines provide a standardized methodology for NT measurement. This is paramount in maintaining the sensitivity of the combined screening as it contributes significantly (about 70% to the 91%) detection rate in the dual test.
Corrected MoMs are MoMs with weight corrections.
Free βhCG is more stable and intact on the DBS card. Also dissociation from free βhCG occurs slow on the DBS card.
One of the most discriminating markers for NTD is AFP which is best accessed from the 15th week for the quadruple test. Hence, the window of the 14 to 15 week is not ideal for dual or quadruple test.
Sensitivity of patau syndrome is very low in the 2nd trimester as pregnancies diagnosed with T13th end in miscarriages between 12 to 15 week of gestation.
LifeCycle risk calculation engine is a comprehensive informatics package for maternal health monitoring and risk assessment. An accessible patient data management system is coupled with a flexible risk calculation engine, which can be configured to meet local variations. Because the system has been fully validated and all calculation methods, algorithms and values are supported by the current published literature, LifeCycle gives full confidence in a maternal risk assessment program.
Pre-eclampsia is a sudden increase in blood pressure and protein in the urine after the 20th week of pregnancy. Pre-eclampsia can lead to eclampsia, or convulsions, posing serious health implications for the mother and the baby. Symptoms of pre-eclampsia may include:
Test Code | Test Name | Sample | Comment/ Description |
---|---|---|---|
SGO61 | Dual Marker Test: (11 – 13.6 weeks) PAPP-A, Free ßhCG | 2 ml serum / DBS Card | NT by USG report (NT & CRL values) and brief clinical history required |
SGO62 | Triple Marker Test: (15 – 21.6 weeks) AFP, ßhCG, uE3 | 2 ml serum | USG report and brief clinical history required |
SGO63 | Quadruple Marker Test: (15 – 21.6 weeks) AFP, ßhCG, uE3, Inhibin – A | 2 ml serum | USG report and brief clinical history required |
PRF2400 | Integrated Test: Dual Marker (First Trimester Screening) & Quadruple Marker (Second Trimester Screening) | 2 ml serum | NT by USG report in 1 trimester & USG report in nd 2 trimester and brief clinical history required |
Test Code | Test Name | Sample | Comment/ Description |
---|---|---|---|
SDO61 | Dual Marker Test: (11 – 13.6 weeks) PAPP-A, Free ßhCG | 2 ml serum | NT by USG report and brief clinical history required |
SDO63 | Quadruple Marker Test: (15 – 21.6 weeks) AFP, ßhCG, uE3, Inhibin A | 2 ml serum | USG report and brief clinical history required, (Patient needs to carry Dual Marker report) |
SDO63 | Prenatal BoBs (Aneuploidies + Microdeletion) | 3 ml Amniotic Fluid / Chorionic Villi | Brief clinical history required |
SDO65 | KaryoLite BoBs | Placental biopsy without blood clot in normal special container provided by Lab | Brief clinical history required |